Genetic Analysis of Inherited Breast and Ovarian Cancer: From Gene Discovery to Precision Medicine and Public Health
日時2023年5月20日（土）
11:00～11:50
座長：太田 智彦
（聖マリアンナ医科大学 大学院医学研究科 応用分子腫瘍学）
Mary-Claire King, PhD
American Cancer Society Professor
Departments of Medicine and Genome Sciences
University of Washington, Seattle
Mary-Claire King is American Cancer Society Professor at the University of Washington in Seattle. She was the first to show that breast cancer is inherited in some families, as the result of mutations in the gene that she discovered and named BRCA1. Her other research interests include the genetic bases of severe mental illness, the genetic causes of birth disorders in children, and human genetic diversity and evolution. She pioneered the use of DNA sequencing for human rights investigations, applying mitochondrial DNA sequencing to the identification of kidnapped children in Argentina and subsequently to cases of human rights violations on six continents.
Dr. King grew up in Chicago. She received her BA cum laude in Mathematics from Carleton College in Minnesota; her PhD in Genetics from the University of California at Berkeley; and her postdoctoral training at UC San Francisco. Her PhD dissertation was the demonstration that protein-coding DNA sequences of humans and chimpanzees are 99% identical. She was professor at UC Berkeley from 1976-1995 and at the University of Washington since 1995.
Dr. King has been elected to the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, the American Philosophical Society, and as a foreign member of the French Academy of Sciences. She is a past president of the American Society of Human Genetics. Her awards include the University of California Medal, the Gruber Foundation Prize in Genetics, the Heineken Prize for Medicine (Netherlands), the Princess Takamatsu Memorial Lectureship (Japan), the Dan David Prize (Israel), the Shaw Prize (Hong Kong), the Gairdner International Award (Canada), the Lasker Foundation Special Achievement Award for Medical Research, and the United States National Medal of Science.
Mary-Claire King博士は1990年にヒト17番染色体の長腕に家族性乳がんの原因遺伝子があることを発見し、その後も数々のBRCAに関する重要な発見をされてきた文字通りHBOC研究の生みの親とも言うべき研究者で、ノーベル賞の登竜門であるラスカー賞をはじめ、多くの賞を受賞されています。 本講演は発見の経緯から最新の研究まで、King博士の魅力あふれるご講演を拝聴できるまたとない機会ですので是非ご参加下さい。多くの先生方のご参加をお待ちしております。（太田智彦）
